Role of Anti-Müllerian Hormone in Gynecology: A Review of Literature
نویسندگان
چکیده
Anti-müllerian hormone (AmH) or müllerian inhibiting substance (mIS), is a dimeric protein part of the transforming growth factor (TGF)-beta subfamily. It plays two important roles in follicle genesis. First, it delays entrance of primordial follicle into pool of follicles in growth and secondly, it decreases the sensitivity of ovarian follicle toward follicle-stimulating hormone (FSH). The ovary-specific expression pattern in granulosa cells of growing non-selected follicles makes AmH an ideal marker for size of the ovarian follicle pool. This review summarizes recent literature concerning AmH and its role in various gynecological conditions. Methods: The literature regarding AmH was searched from various English language journals and published peer-reviewed articles on Pubmed, mEDLINE and Google Scholar till 2014.
منابع مشابه
Decreased serum anti-Müllerian hormone levels in girls with newly diagnosed cancer
W. van Dorp1,2,*, M.M. van den Heuvel-Eibrink2, A.C.H. de Vries2, S.M.F. Pluijm2, J.A. Visser3, R. Pieters2, and J.S.E. Laven1 Division of Reproductive Medicine, Department of Obstetrics and Gynaecology, Erasmus MC-University Medical Centre Rotterdam’s– Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands Department of Paediatric Oncology/Haematology, Erasmus MC-Sophia Children’s Hospital, Dr....
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